One thing that often masquerades like an IgE allergy, but is not, is histamine excess. An excess of histamine of course can produce all the same symptoms with itching, swelling, wheeze, rhinitis etc….so how do we get a histamine excess without raised basophils and exposure to allergens? Well there’s something called ‘Histamine Intolerance’ which refers to an inefficient or overloaded histamine detoxification system, and although well recognised in Europe is not really talked about here.
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