Working in mental health? Do you wonder which of your patients really should be tested for pyrroles so you can avoid wasting your time and their money, for the rest? At last, urinary pyrroles as a biological driver, is moving in from the margins of pseudo-science and starting to be the subject of more rigorous research. With these investigations have come the opportunity to test our old ideas about what to look for and who to test…and surprise! many of those old markers and traits have been thrown out as a result. It’s time to smarten up our knowledge in this area and our ability to Pick up on Pyrroles.