Following the important discovery of the role of intestinal zonulin in the pathophysiology of coeliac disease our fascination with measuring zonulin in non-coeliac patients suspected of ‘leaky gut’, has moved faster than the facts. It’s time to critically reassess what value, if any, there is in testing serum zonulin – which patients and when? And what is the true gold standard for detecting increased intestinal permeability in our patients?
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