While this ABC article is written for the public it’s a great checklist to have written up somewhere to prevent against placing your confidence in the wrong sources of info.
Just recently, I had a practitioner ask about the ‘risks’ of B12 dosing…& while B12 is considered to be free of a toxicity profile in just about any textbook or in-depth review paper you can find, a ‘methylation’ expert had made mention of there being demonstrated increased oxidative stress.
My response, ‘Have you checked their references?’
I get it, right, we’re all busy people and don’t have the time for a full literature review of every claim made by every educator, ‘expert’ or company… BUT sometimes a credibility check can be lightning fast!!!! As was the case in this instance.
I did check this expert’s reference (singular). I read the full article just out of interest but actually, I didn’t need to. I had my answer just by reading the title and abstract…the study was conducted in genetically altered rats made alcoholic and injected with B12 or something to that effect. Relevance?? Which is in stark contrast to the absolute consensus from 100s of human studies concluding that B12 toxicity is NOT a thing.
That also means this particular expert’s references probably need to be checked every time of course…until you can be more confident in the quality of their claims – tough but true. Below are the 7 top Qs to try and answer to determine the quality of any claim – and remember you rarely have to complete the list to get your answer…just start with reading the title of their key reference!!!
1. Who says? (….and what agenda/bias might they have)
2. Sample size ( a response rate of 20% might mean something in a sample of 10000 & nothing in a sample of 10!)
3. Lab-bench or real world
4. Correlation V causation
5. Statistically significant V clinically significant (…if something was shown to reduce people’s migraine pain by a rating of 0.5 – but most people rate their pain at 10/10…is it actually clinically meaningful?!)
6. Does the dose relate? (…watch out for animal studies where they are using doses at mg/kg body weight…that we could never match with oral dosing in humans because they would be eating buckets of the stuff!)
7. Got some time?…then dig a little deeper…if your article has passed all the above checkpoints and you’re still dubious (and this does happen!) check out who has cited this paper (easy via Google Scholar) and whether other researchers are in agreement or not with their findings. What’s been published in this area since then?
Oh and this article is also handy for the occasional misguided patient – who’s found some incredulous online info about something that contradicts your contrastingly well-sourced & quality-checked knowledge! 😉
Our new – New Graduate Mentoring Program kicks off in late January and offers an incredible opportunity for successful applicants to develop their core clinical competencies in record time during their transition into practice. Real world research cheat tips, is just one of the many practical competencies covered across the year’s curriculum. But if you’re interested in applying, jump onto it! Applications close on the 15th November